Author: Diamond, Adele.; Prevor, Mereedith B.; Callender, Glenda; & Druin, Donald P.
Title: Prefrontal Cortex Cognitive Deficits in Children Treated Early and Continuously for PKU
Description: Chicago, University of Chicago Press, 1997. orig.wrappers. 23x15cm, v, 208 pp. Series: Monographs of the Society for Research in Child Development, Vol. 62, No. 4.. Textual illustrations. Minor rubbing. VG. ¶ Contents: Abstracts; Introduction; Participants; Procedures; Results: Phenylalanine Levels and IQ; Results: Infants; Results: Toddlers; Results: Young Children; Conclusions; References; Acknowledgments; Contributors; Statement of Editorial Policy...."The metabolic disorder phenylketonuria ( PKU) is the most common biochemical cause of mental retardation, and affects roughly one in 10,000 children. Bridging basic neuroscience research and clinical studies, this longitudinal study provides evidence that cognitive deficits result from even moderate amino acid imbalances considered acceptable under the standard treatment for PKU; characterizes the nature of those cognitive deficits; and identifies their biological cause. The authors discuss possible steps to correct the problem, and possible implications of the findings for children with other developmental disabilities, such as Attention Deficit Disorder." Publisher's description

Keywords: Pediatric Medicine, Cognition Disorders, Child Development, Childhood, Phenylketonuria, Preforntal Cortex, Brain Physiology, Developmental, Cognitive