Author: PASTEUR, L.
Title: Sur les maladies virulentes et en particulier sur la maladie appelée vulgairement choléra des poules.
Description: Paris, Gauthier-Villars, Impr. libraire, des comptes rendus de l'académie des sciences..., 1880. large 4to. Original half clf., w. red spine label for the title and a green spine label for the volume number. ( Bottom of spine some dam.). [quire 31-4recto to 32-4verso]. (Pp. 239 - 248). [In: Comptes rendus, vol. 90, nr 6, febr. 1880] Pasteur's classic article published in: 'Comptes rendus hebdomadaires des Séances de l'Académie des Sciences', Volume 90, nr. 6, 'Séance du Lundi février 1880, covering the pages (233), 234 - 260.: DSB vol. X, pp. 350 - 416 [specifically pp. 390/92:] '"The disease is its own preventive"... What gave this result special importance and novelty was the demonstrably microbial nature of fowl cholera. Preventive inoculations were not new but they had never been used against a disease known to be caused by a microorganism that might be cultivated outside of living organisms. Never had it been known that the property of nonrecurrence, associated with the so-called virus diseases, could belong to a microbial disease. Fowl cholera thus formed the first clear link between microbial diseases and diseases "in the virus of which life has never been recognized".': Grolier 100, Medicine, item 78: 'Variolation, the practice of inoculating with with infected material from smallpox cases, had been proven to to accomplish similar results, and Edward Jenner... demonstrated at the end of the eighteenth century tha cowpox vaccination provided a safer and more efficacious approach to small pox immunity. However, the MECHANISM RESPONSIBLE FOR THIS PROTECTION and the means of extending it to other infectious diseases remained a mystery until Louis Pasteur published THE PRESENT PAPER. This established the field of immunology as an experimental science, ...': G&M 2537: 'This paper marked the beginning of Pasteur's work on the attenuation of the infective organism. Noting that fowls inoculated with an attenuated form of chicken cholera bacterium acquired immunity, he developed the idea of a protective inoculation by attenuated living cultures, and subsequently adopted this principle with anthrax, rabies, and swine erysipelas... [Since 1979] ...Pasteur's original laboratory notebooks has provided evidence that Emile Roux played a crucial and previously unacknowledged role in the development of the vaccine...': PMM366e: 'Comp. Norman Coll. II, 1661: 'Pasteur isolated the fowl cholera microbe (Pasteurella multocida) and demosntrated that it was the true cause of the disease. By varying his methods of culturation, he discovered a means of decreasing the microbe's virulence; a chicken inoculated with this attenuated microbe, although contracting the disease, would usually recover and be henceforth relatively immune to the highly virulent form. This was the first example of preventative inoculation for a disease caused by an identifiable micro organism, one that could be isolated and cultivated outside of living organisms; ...':

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