Author: GOLDMANN, Edwin E.
Title: Vitalfärbing am Zentralnervensystem. Beitrag zur Physio-Pathologie des Plexus Chorioideus und der Hirnhäute.
Description: Berlin, Verlag d. Königl. Akademie der Wissenschaften, 1913. 4to. W. 4 col. lith. plates. Contemp. half cloth over paste paper brds., green printed wrapper of 'Abhandlungen' laid down on upper cover. Paper title shield on spine. (Wr. soiled; lower board dam.due to water; edges of covers badly rubbed.). (XXXVIII [the proceedings and minutes] 60 [Goldmann's contribution] pp.). (Condition of binding below avarage; interior text and plates very good.). Published in the 'Abhandlungen der Königl. Preuss. Akad. d. Wissenschaften', Jahrgang 1913 Physikalisch Mathematischen Classe. Garrison / MacHenry, p. 367: 'He demonstrated that trypan blue injected into the cerebrospinal fluid will cause the brain to be coloured a deep blue, whereas intravenous trypan blue does not stain the brain.': Clarke / O'Malley, p. 749: 'Goldmann was the first to carry out a series of experiments that proved the existence of the blood - brain barrier. Using vital dyes, and in particular trypan blue, Goldmann studied the permeability of the barrier. By the intravenous and intrathecal administration of trypan blue he found that the barrier was impermeable to its larger molecules, and he concluded that the choroid plexuses were the site of the holdup.... In it [the monograph] he referred to chemotherapy of the nervous system which was not, however, to be introduced for 30 years.'

Keywords: medicine nerves vitalfärbung pathology Neurology Doos37