KOCH, R. - Untersuchungen über die Aetiologie der Wundinfektionskrankheiten.

Leipzig, J.B. Hirschfeld, Verlag von F.C.W. Vogel, 1878. 8vo. W. 3 tinted lith. pls. (2 double page containing pls. I and II & III & IV; single page plate numbered V) by ['lith. Anst. v.'] E.A.Funke. Contemp. hlf. publ. cloth over marbled brds. (Spine some discol.; slight dam. to spine ends.). [n2, 1 - 5 in 8s.]. (IV, 80 pp.). (Sign. in ink on upper free endp. [Dr. E. Kvester]; Bookplate of the same on upper paste down. endp.). (Verso printed title a small oval libr stamp 'Prof. Dr. Med. Hermann Werner Siemens'). First edition of Koch's epochal first monograph, in which he proved the role of bacteria as the source of wound infections. DSB VII, 420 - 435: Heinrich Hermann Robert Koch, 1843 - 1910. Bacteriology, hygiene, tropical medicine. '...Koch's first monograph ...This work reported his findings on the bacteriology of infected wounds - a problem still unsettled a decade after Joseph Lister introduced antisepsis. ...Koch induced artificial infections in mice and rabbits by injecting putrid fluids. ...he first explicitly stated the criteria implicit in Henle's essay on contagion, which after modification became known as "Koch's postulates." ... Koch identified 6 transmissable infections, two in mice and four in rabbits, that were pathologically and bacteriologically distinctive. He deduced that human traumatic infections would prove similarly due to specific parasites and concluded that his experiments illustrated the diversity and immutability of pathogenic bacteria. Among favorably impressed surgeons were Lister and Theodore Billroth, who thereafter strongly supported him.': G&M 2356 'Koch's epochal work on the aetiology of traumatic infectious disease established his reputation ...His great work determined the role of bacteria in the aetiology of wound infections and demonstrated for the first time the specificity of of infection.': Norman Collection, 1229: Norman Sale III, 1151: Comp. Grolier, medicine, 80, note '...a pioneer in the use of the microscope in bacteriological research ... In this work Koch first developed procedures for staining bacteria in diseased tissues with aniline dyes, procedures that were to become critical in his research on tuberculosis a few years later.': Heirs of Hippocrates 2053: Osler 1687: PMM 366b: Waller 5345:

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